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Pathways Recommended:	Stem Cell/Wnt Neuronal Signaling JAK/STAT Signaling

Results for "

Wnt/β-catenin signal inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ERK (1) Wnt (33) β-catenin (32) Antibiotic (2) Apoptosis (6) Autophagy (5) Bacterial (2) Bcl-2 Family (1) Carbonic Anhydrase (1) Casein Kinase (2) CDK (5) E1/E2/E3 Enzyme (1) Glucocorticoid Receptor (2) GSK-3 (6) Histone Acetyltransferase (1) JNK (1) Mitophagy (1) MMP (1) NF-κB (2) Organoid (4) P-glycoprotein (1) p38 MAPK (1) Parasite (2) PARP (2) Phosphodiesterase (PDE) (2) Reactive Oxygen Species (1) STAT (2) Survivin (1)
By Research Areas:	Cancer (37) Cardiovascular Disease (2) Endocrinology (2) Infection (1) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (5)

By Targets:

ERK (1)

Wnt (33)

β-catenin (32)

Antibiotic (2)

Apoptosis (6)

Autophagy (5)

Bacterial (2)

Bcl-2 Family (1)

Carbonic Anhydrase (1)

Casein Kinase (2)

CDK (5)

E1/E2/E3 Enzyme (1)

Glucocorticoid Receptor (2)

GSK-3 (6)

Histone Acetyltransferase (1)

JNK (1)

Mitophagy (1)

MMP (1)

NF-κB (2)

Organoid (4)

P-glycoprotein (1)

p38 MAPK (1)

Parasite (2)

PARP (2)

Phosphodiesterase (PDE) (2)

Reactive Oxygen Species (1)

STAT (2)

Survivin (1)

By Research Areas:

Cancer (37)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (1)

Inflammation/Immunology (8)

Metabolic Disease (5)

Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Wnt β-catenin ERK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115539

Windorphen	Wnt β-catenin Histone Acetyltransferase	Cancer
Windorphen is a *Wnt/β-catenin* signal inhibitor that specifically targets the function of the c-terminal transactivation domain of *β-catenin-1* but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP .

HY-120697

MSAB 10+ Cited Publications	Wnt β-catenin	Cancer
MSAB is a potent and selective inhibitor of *Wnt/β-catenin* signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells .

HY-121118

Coronaridine 1 Publications Verification	Wnt	Neurological Disease Cancer
Coronaridine, an iboga type alkaloid, inhibits the **wnt signaling** pathway by decreasing β-catenin expression .

HY-160489

PTK7/β-catenin-IN-2	β-catenin	Cancer
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of *PTK7/β-catenin*. It inhibits the binding of PTK7 to β-catenin (IC₅₀: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC₅₀ of 157.1 μM .

HY-160493

PTK7/β-catenin-IN-6	Wnt β-catenin	Cancer
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .

HY-13815

KY02111 5 Publications Verification	Wnt	Cardiovascular Disease
KY02111 is a canonical **WNT signaling (β-catenin)** inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration .

HY-163409

CGK012	β-catenin	Inflammation/Immunology Cancer
CKG012 is an inhibitor for *Wnt/βcatenin* signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer .

HY-112799

DK419	Wnt β-catenin	Cancer
DK419 is a potent and orally active *Wnt/β-catenin* signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .

HY-133180

YW1128	Wnt β-catenin	Metabolic Disease
YW1128 (compound 3a) is a potent *Wnt/β-Catenin* inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism .

HY-18959

CWP232228 4 Publications Verification
CWP232228, a highly potent selective *Wnt/β-catenin* signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

HY-108442

JW67 1 Publications Verification	Wnt	Cancer
JW67 inhibits the canonical *Wnt* signaling with an IC₅₀ of 1.17μM . JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of *Wnt* target genes. JW67 also inhibits colorectal cancer cell growth .

HY-160709

Wnt/β-catenin-IN-2	Wnt β-catenin	Cancer
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a *Wnt/β-catenin* signaling pathway inhibitor, with IC₅₀ and K_D values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer .

HY-138301

Miclxin DS37262926	β-catenin	Cancer
Miclxin (DS37262926) is a potent inhibitor of mutant *β-catenin, involving in Wnt* signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .

HY-157990

Wnt/β-catenin-IN-1	Wnt β-catenin	Cancer
Wnt/β-catenin-in-1 (compounds 17) is a *Wnt/β-catenin* signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors .

HY-155391

hCA/Wnt/β-catenin-IN-1	Carbonic Anhydrase P-glycoprotein Wnt β-catenin	Cancer
hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (K_i: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits *Wnt/β-catenin* signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line .

HY-12238

IWR-1

25+ Cited Publications

endo-IWR 1; IWR-1-endo
Organoid Wnt Cancer

IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

IWR-1 25+ Cited Publications endo-IWR 1; IWR-1-endo	Organoid Wnt	Cancer
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

HY-16910

WIKI4 2 Publications Verification	PARP β-catenin	Cancer
WIKI4 is a potent tankyrase inhibitor with an IC₅₀ of 26 nM for TNKS2. WIKI4 potently inhibits *Wnt/β-catenin* signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on *Wnt/β-catenin* signaling by inhibiting the enzymatic activity of TNKS2 . WIKI4 is cytotoxic to SCLC cells with an IC₅₀ value of 0.02 μM .

HY-137454

Teplinovivint	Wnt β-catenin	Inflammation/Immunology
Teplinovivint is a potent *wnt/β-catenin* signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research .

HY-115543

β-catenin-IN-37	β-catenin	Cancer
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC₅₀ values of 20 μM and 31 μM, respectively .

HY-111460

15-Oxospiramilactone NC 043	Wnt	Cancer
15-Oxospiramilactone is a diterpene derivative. 15-Oxospiramilactone can inhibit *Wnt/β-catenin* signaling and tumorigenesis of colon cancer cells .

HY-145267

OM-153	PARP Wnt	Cancer
OM-153 is a potent and orally active tankyrase inhibitor with IC₅₀s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based *Wnt/β-catenin* signaling reporter activity with an IC₅₀ value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM .

HY-153214

YW2036

Wnt β-catenin Cancer

YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC₅₀ value of 637 nM. YW2036 can be used in research of cancer .

YW2036	Wnt β-catenin	Cancer
YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC₅₀ value of 637 nM. YW2036 can be used in research of cancer .

HY-108441

CCT031374 hydrobromide	β-catenin	Cancer
CCT 031374 hydrobromid is a potent inhibitor of β-catenin/transcription factor (TCF) complex signaling. CCT031374 inhibits TCF-dependent transcription of genes of Wnt signaling pathway. CCT 031374 has antitumor activity .

HY-N0020

Echinacoside 5+ Cited Publications	Wnt Reactive Oxygen Species	Neurological Disease
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits **Wnt/β-catenin signaling*. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal* pathways. Antiosteoporotic activity .

HY-117233

UU-T02	β-catenin Wnt	Metabolic Disease Cancer
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction *(β-catenin/Tcf PPI)* with a K_i of 1.36 μM . UU-T02 inhibits canonical *Wnt* signaling and the growth of colorectal cancer cells .

HY-17439

Salinomycin sodium salt 20+ Cited Publications Salinomycin sodium; Sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of *Wnt/β-catenin* signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells .

HY-15597

Salinomycin 20+ Cited Publications Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of *Wnt/β-catenin* signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells .

HY-W010995

2,5-Dimethylcelecoxib	Wnt Survivin β-catenin	Cancer
2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the *Wnt/β-catenin* signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin .

HY-141891

M435-1279	E1/E2/E3 Enzyme	Cancer
M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the *Wnt/β-catenin* signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1 .

HY-18285

Longdaysin	Casein Kinase ERK CDK	Cancer
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC₅₀s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively .

HY-108437

exo-IWR-1	Wnt	Infection Cancer
exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1 (HY-12238). IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway .

HY-151463

CDK8-IN-11	CDK β-catenin	Cancer
CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC₅₀ value of 46 nM. CDK8-IN-11 inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 can be used in the research of colon cancer .

HY-151463A

CDK8-IN-11 hydrochloride	CDK β-catenin	Cancer
CDK8-IN-11 hydrochloride is a potent and selective CDK8 inhibitor with an IC₅₀ value of 46 nM. CDK8-IN-11 hydrochloride inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 hydrochloride can be used in the research of colon cancer .

HY-119711

NNGH	MMP	Cancer
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression .

HY-P2272

NLS-StAx-h	Wnt β-catenin	Cancer
NLS-StAx-h is a selective, cell permeable, stapled peptide *Wnt* signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells .

HY-12762

QS11 1 Publications Verification	Others	Cancer
QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC₅₀ of 1.5 µM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells .

HY-N3149A

2-Hydroxycinnamaldehyde	Wnt β-catenin STAT Apoptosis	Inflammation/Immunology
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits *Wnt/β-catenin, STAT3* signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities .

HY-P2272A

NLS-StAx-h TFA	Wnt β-catenin	Cancer
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide *Wnt* signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells .

HY-N0279

Cardamonin 5+ Cited Publications Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, *Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-14930A

Mirodenafil dihydrochloride SK-3530 dihydrochloride	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the *Wnt/β-catenin* signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-14930

Mirodenafil SK3530	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the *Wnt/β-catenin* signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-N0665

Specnuezhenide 1 Publications Verification (8E)-Nuezhenide	NF-κB Wnt	Inflammation/Immunology
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and *wnt/β-catenin* signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-10456

TAK-715 10+ Cited Publications	p38 MAPK Casein Kinase	Inflammation/Immunology
TAK-715 is an orally active and potent p38 MAPK inhibitor with IC₅₀s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model .

HY-131447

KY19382 1 Publications Verification A3051	GSK-3 Wnt β-catenin	Metabolic Disease
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC₅₀s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases .

HY-145669

DIF-3 1 Publications Verification	CDK GSK-3	Cancer
DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression .

HY-10182

Laduviglusib Maximum Cited Publications 141 Publications Verification CHIR-99021; CT99021	Organoid GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent *Wnt/β-catenin* signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy .

HY-10182B

Laduviglusib trihydrochloride Maximum Cited Publications 141 Publications Verification CHIR-99021 trihydrochloride; CT99021 trihydrochloride	Organoid GSK-3 Wnt β-catenin Autophagy	Cancer
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent *Wnt/β-catenin* signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy .

HY-10182A

Laduviglusib monohydrochloride Maximum Cited Publications 141 Publications Verification CHIR-99021 monohydrochloride; CT99021 monohydrochloride	Organoid GSK-3 Wnt β-catenin Autophagy	Cancer
Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent *Wnt/β-catenin* signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy .

HY-139254

Indirubin-3′-oxime IDR3O; I3O	CDK GSK-3 JNK	Neurological Disease
Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC₅₀s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes .

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